Right from the start, head to the nearest jump pad and get up there. What you want to do is use the awnings that cover the level to quickly move about. The easiest way to get this achievement is to play CTF on Overlook. This one probably won't help much toward ach but the other one will!' It is not in the direct center of the roof but you will see it when you get up there. Now go towards the middle and you should see it up there. Once you have a jetpack mutator active, fly on one of the edges of the map and ascend until you reach the roof. Now for the harder mutator which you need the jetpack to reach. You will be on a secret lower path with a big armor pickup, mutator, and jumppad to get back up. You should see a blue sphere on a wall near the edge of the map. Go to the side of the map that has a jumppad and when you go up it will be straight forward in front of you. The one that is easy to reach is near another known mutator. 'After getting 200 and playing this game over 50 hours, I actually just now found out that there are actually 7 total mutator spawns in this level - one being easily accessible and the other only accessible by jetpack. Some additional, helpful information from K4rn4ge: Or there are more requirements that are unknown (such as the type of mutator). I definitely used over 25, so this achievement seems a bit iffy.

I unlocked it near the end of the match (had little time left over even with 3 stop clocks used). I spent the entire CTF match running from point to point taking mutators and using them. I unlocked this on the map Vigor which has 5 mutator spawn points.

Nexuiz dynamic mutators